A total of 119 subjects were found to have intestinal polyps, including 61 cases of hyperplastic polyps and 58 cases of adenomas, and no significant difference was found in ANA positivity rate between intestinal polyp and polyp-free participants. Keywords: antinuclear antibodies; autoimmune diseases; gastrointestinal lesions; healthy population EN antinuclear antibodies autoimmune diseases gastrointestinal lesions healthy population 1849 1852 4 09/06/23 20230901 NES 230901 INTRODUCED Antinuclear antibodies (ANA), as an important marker of autoimmune diseases, is widely used in the screening, diagnosis and follow-up of autoimmune diseases. In summary, ANA may be associated with gastrointestinal tract tumors, cardiovascular events and all-cause mortality, in addition to being a warning sign of autoimmune diseases. DISCUSSION ANA is an important marker of autoimmune diseases and can be positive several years before the onset of autoimmune diseases. [Extracted from the article]