Rhinovirus infection and IFN- both increased I MUC5AC i and I MUC5B i mRNA expression, whereas apical MUC5AC release was only elevated after RV infection. Sajuthi et al.[11] demonstrated that I MUC5AC i and I FOXA3 i genetic variants are linked to airway mucus pathobiology in asthma, and our results here suggest that FD could alleviate MUC5AC-driven effects in asthma. Whether FD reduces mucus hypersecretion upon RV infection and thus limits childhood wheeze and asthma development remains to be investigated. Farm dust reduces mucin production in rhinovirus-infected primary bronchial epithelial cells. [Extracted from the article]