Requirement of Type III TGF-beta Receptor for Endocardial Cell Transformation in the Heart.
- Resource Type
- Article
- Authors
- Brown, Christopher B.; Boyer, Angelique S.; Runyan, Raymond B.; Barnett, Joey V.
- Source
- Science; 3/26/1999, Vol. 283 Issue 5410, p2080-2082, 3p, 6 Color Photographs, 2 Black and White Photographs, 6 Graphs
- Subject
- Transforming growth factors-beta
Cell transformation
Heart cells
Transforming growth factors
- Language
- ISSN
- 00368075
Reports that the transforming growth factor-beta (TGF-beta) type III receptor (TBRIII) lacks a recognizable signaling domain and has no clearly defined role in TGF-beta signaling. Expression of TBRIII in cardiac endothelial cells that undergo epithelial-mesenchymal transformation; Other findings; Support of results for a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-beta signaling.