Qualitative and quantitative analysis of the chemical components in Yuquan capsules by using ultra‐performance liquid chromatography‐mass spectrometry.
- Resource Type
- Article
- Authors
- Wu, Fangfang; Tan, Zhien; Li, Taiping; Zhang, Mengli; He, Yanmei; Chen, Shimin; Yu, Pan; Ou, Min; Liu, Lingjie; Wang, Xijun
- Source
- Journal of Separation Science. Aug2023, Vol. 46 Issue 16, p1-16. 16p.
- Subject
- *LIQUID chromatography-mass spectrometry
*QUALITATIVE chemical analysis
*QUANTITATIVE chemical analysis
*TIME-of-flight mass spectrometry
*CHINESE medicine
*QUADRUPOLE ion trap mass spectrometry
- Language
- ISSN
- 1615-9306
The Yuquan capsules is a commonly used traditional Chinese Patent Medicine used for the treatment of diabetes mellitus. In this study, a high‐throughput analytical method for identifying the chemical composition of Yuquan capsules was established for the first time by using ultra‐performance liquid chromatography–quadrupole time of flight mass spectrometry. The data obtained were subjected to fragment analysis and this was combined with UNIFI processing of natural products. One‐hundred sixteen compounds were characterized from Yuquan capsules. Twelve of the bioactive compounds were quantitatively analyzed by ultra‐performance liquid chromatography‐tandem triple quadrupole mass spectrometry. This study was undertaken to obtain a comprehensive chemical profile analysis as well as to evaluate the overall quality of Yuquan capsules. The results will provide a reference for the quality evaluation of different Yuquan preparations. In addition, the data will enable basic pharmacodynamic research into these extensively used capsules. [ABSTRACT FROM AUTHOR]