Background:: Osteoarthritis (OA) is a disease with progressive loss of articular cartilage, which is due to a variety of genetic and environmental risk factors and pathophysiological processes. The main cause of trauma and discomfort in joint mobility leading to disability in osteoarthritis is simultaneous new bone generation and synovial growth. Disruption of articular cartilage, osteophyte generation, subchondral sclerosis, meniscal disintegration, bone marrow lesions, and synovial proliferation are the typical characteristics of osteoarthritis (OA) (1) The progression and morbidity due to arthritis can be reduced significantly with the help of early diagnosis of OA knee joint with detailed clinical history with the help of a simple questionnaire, X-ray evaluation, and baseline biochemical tests can help to initiate early intervention in the form of analgesics and physiotherapy with follow-up. Early structural changes in the disease may also be captured with the help of imaging studies and this can help in the initiation of therapy at an earlier stage and good outcome of the disease Detection of those subjects with co-morbidities and with early knee, OA may offer an opportunity to successfully intervene in the disease and reduce the burden on patients and the community. Aim: To evaluate the effectiveness of an integrated approach to clinical assessment and management in the whole sample population. Methods: According to the sample size calculation, a total of 70 patients were selected after screening and exclusion. Baseline characteristics and clinical scores of 70 patients were recorded. The patients were followed up after 3 months and 6 months for clinical scores. Informed written consent in a language understood by the patient was taken. Personal data, clinical findings, radiological findings, biochemical reports, and related medical records of all patients were obtained. A pre-tested semi-structured questionnaire was administered to all patients. The second part was comprised of the possible risk factors for developing OA of the knee such as age, gender, body mass index, occupation, family history of OA, physical activity, history of injury to the knee, etc. X-ray, weight, and height measurements along with all necessary investigations according to the standard protocol were done. Results: An almost equal number of elderly (above the age of 60) and non-elderly were involved in the study. Hence it could be concluded that early changes in knee OA may not necessarily be age dependent. After analyzing a total of 70 patients in the study, it was observed that there was almost an equal distribution of males and females in the study. On the evaluation of BMI of the individual patients, it was noticed that the majority of the patients belonged to either the overweight or obese class. The majority of the patients were found to be vitamin D deficient and patients were anemic. Those patients were given supplementation accordingly. Conclusion: All patients of early knee OA are presently getting benefitted from an integrated approach where clinical examination, imaging techniques, and laboratory investigations are used systematically and routinely for clinical assessment while simultaneously exercise, lifestyle modifications, and medication is used for the management of knee OA. Each risk factor associated with knee OA is studied individually as a subset and thus can be of great future research potential. [ABSTRACT FROM AUTHOR]