Tumorous fibrosis, such as desmoplasia and fibrous hyperplasia, is a typical characteristic led by interventional embolization and selective internal radiotherapy. In this study, 68Ga-FAPI-04 PET/CT was used to evaluate in situ hepatocellular carcinoma of rat models after TARE operation and compared with 18F-FDG PET/CT. The results showed that the reflection of pathological changes in fibrosis by 68Ga-FAPI-04 PET/CT depends on the time-points of postoperative imaging in evaluating tumor treated with TARE. Conclusively, 68Ga-FAPI-04 PET/CT can be used to assess fibrosis changes after TARE and correspond to pathological changes, providing an important supplement to the current assessment with 18F-FDG PET/CT. [ABSTRACT FROM AUTHOR]