Intermediate monocytes expansion and homing markers expression in COVID-19 patients associate with kidney dysfunction.
- Resource Type
- Article
- Authors
- Dentone, Chiara; Fenoglio, Daniela; Parodi, Alessia; Altosole, Tiziana; Di Biagio, Antonio; Bozzano, Federica; Nasi, Giorgia; Vena, Antonio; Fabbi, Marina; Ferrera, Francesca; Bruzzone, Bianca; Giacomini, Mauro; Giacobbe, Daniele Roberto; Pelosi, Paolo; De Maria, Andrea; Bassetti, Matteo; De Palma, Raffaele; Filaci, Gilberto
- Source
- Clinical & Experimental Medicine. Aug2023, Vol. 23 Issue 4, p1235-1242. 8p.
- Subject
- *COVID-19
*MONOCYTES
*CHEMOKINE receptors
*KIDNEYS
*KIDNEY diseases
- Language
- ISSN
- 1591-8890
Patients with severe SARS-CoV-2 infection have an overwhelming inflammatory response characterized by remarkable organs monocyte infiltration. We performed an immunophenotypic analysis on circulating monocytes in 19 COVID-19 patients in comparison with 11 naïve HIV-1 patients and 10 healthy subjects. Reduced frequency of classical monocytes and increased frequency of intermediate monocytes characterized COVID-19 patients with respect to both HIV naïve patients and healthy subjects. Intensity of C–C motif chemokine receptor 2 (CCR2) monocyte expression highly correlated with parameters of kidney dysfunction. Our data indicate that highly activated monocytes of COVID-19 patients may be pathogenically associated with the development of renal disease. [ABSTRACT FROM AUTHOR]