Based on our previous work, in which acute intravenous hormone infusion reduced food intake in healthy men,[11] a sample size of 16 people would have 90% power (at a significance level of 0.05) to detect a clinically significant reduction in food intake of 2.3 ± 1.3 kcal/kg. This is the first study to report on the effect of kisspeptin on appetite, food intake, glucose and insulin levels in women, and in people who are overweight or have obesity. Keywords: appetite control; experimental pharmacology; randomized trial; weight control EN appetite control experimental pharmacology randomized trial weight control 2393 2397 5 07/04/23 20230801 NES 230801 BACKGROUND Kisspeptin is recognized to have a critical role in the control of reproductive function[[1]]; however, as reproductive processes require adequate energy stores, there is increasing focus on its interaction with metabolic processes. (B) Luteinizing hormone (LH) levels were higher during kisspeptin infusion compared with vehicle infusion (**p < .01). gl Serum insulin, plasma glucose, serum luteinizing hormone (LH) and serum oestradiol were measured in the Clinical Chemistry Laboratory of Imperial College Healthcare NHS Trust. [Extracted from the article]