Polymerase- -deficiency as a novel cause of inborn cancer predisposition associated with human papillomavirus infection Planned immunization with a licensed nonavalent HPV vaccine will give insight into the patient's ability to mount a protective neutralizing immune response to mucosal genus HPV types. Https://doi.org/10.1093/bjd/ljad021 Dear Editor, In 2019, we identified polymerase- deficiency to be causative of a novel type of syndromic combined immunodeficiency in two patients.[1] Patient 2 originally presented with short stature, microcephaly, lymphopenia and skin warts. [Extracted from the article]