Q-switched 1064 nm Nd:YAG laser treatment activates the TGFBR1-SMAD4-Col3a1 axis to rejuvenate the photoaged skin of Wistar rats, at least partly by downregulating miR-27a-3p. TGFBR1 and SMAD4 are direct targets of miR-27a-3p in the skin, it suggested that the laser treatment activates the TGFBR1-SMAD4-Col3a1 axis, at least partly by downregulating miR-27a-3p. Nd: YAG laser activates the TGFBR1-SMAD4-Col3a1 axis via miR-27a-3p in photoaged rat skin Keywords: Lasers; MicroRNAs; SMAD4; TGFBR1 EN Lasers MicroRNAs SMAD4 TGFBR1 269 272 4 05/11/23 20230501 NES 230501 INTRODUCTION Skin photoaging is induced by long-term ultraviolet (UV) irradiation, especially UVA (315-400 nm) and UVB (280-315 nm). [Extracted from the article]