lncRNA IGF2‐AS regulates miR‐500a‐3p/PPP4R1/p‐VEGFR2 signalling pathway to promote thyroid carcinoma progression and tubulogenesis.
- Resource Type
- Article
- Authors
- Xiang, Yuan; Zong, Qi‐Bei; Liu, Hui; Li, Han‐Ning; Wu, Qi‐Fang; Dai, Zhou‐Tong; Huang, You; Shen, Chao; Li, Le‐Wei; Li, Xing‐Rui; Liao, Xing‐Hua
- Source
- Clinical & Translational Medicine. Apr2023, Vol. 13 Issue 4, p1-4. 4p.
- Subject
- *NON-coding RNA
*THYROID cancer
*LINCRNA
*CELLULAR signal transduction
*VASCULAR endothelial growth factor receptors
*THYROTROPIN receptors
- Language
- ISSN
- 2001-1326
(D) Fluorescence in situ hybridisation (FISH) was performed with Cy3-labelled IGF2-AS probes (red) and FITC-labelled miR-500a-3p probes (green) to detect the location of IGF2-AS and miR-500a-3p in K1 cells. LncRNA IGF2-AS regulates miR-500a-3p/PPP4R1/p-VEGFR2 signalling pathway to promote thyroid carcinoma progression and tubulogenesis *p < .05; **p < .01; ***p < .001; ****p < .0001. gl To investigate the biological effect of IGF2-AS in thyroid carcinoma cells, RNA-short hairpin RNAs (shRNAs) were used to specifically knockdown IGF2-AS expression. [Extracted from the article]