Thiocyanation of Allylic Alcohols Promoted by Trifluoroacetic Acid.
- Resource Type
- Article
- Authors
- Xia, Wen; Hu, Liangzhen; Ma, Chenglong; Cao, Jiaqi; Zhang, Xiaohui; Xiong, Yan
- Source
- European Journal of Organic Chemistry. 4/20/2023, Vol. 26 Issue 16, p1-5. 5p.
- Subject
- *TRIFLUOROACETIC acid
*ALLYL alcohol
*INDUSTRIAL capacity
*THIOCYANATES
*FUNCTIONAL groups
*INDUSTRIAL applications
- Language
- ISSN
- 1434-193X
A rapid and efficient acid‐promoted strategy to access allylic thiocyanates using allylic alcohols as substrates and easily‐available NH4SCN as the thiocyanate source is presented under metal‐ and oxidant‐free conditions. Through screening of various kinds of acids, organic and strong trifluoroacetic acid (TFA) was found most effective. Testing of substrates showed that the strategy has remarkable functional group tolerance. A possible mechanism is provided, and the gram‐scale experiment demonstrate that this novel protocol has potential industrial application value. [ABSTRACT FROM AUTHOR]