AA, advanced adenoma; CRC, colorectal carcinoma; 5mC, 5-methylcytosine; 5hmC, 5-hydroxymethylcytosine. gl In summary, 5mC and 5hmC showed dynamic changes in the progression of AA-CRC transformation. CRC, colorectal carcinoma; DMGs, differentially methylated genes; 5mC, 5-methylcytosine; 5hmC, 5-hydroxymethylcytosine; RT-qPCR, real-time quantitative polymerase chain reaction. gl To elucidate the mechanism of AA-CRC transformation, the levels of DNA methylases and demethylases were measured. Globally, colorectal carcinoma (CRC) ranks third in terms of prevalence according to the latest Global Cancer Statistics.[1] Studies have shown that most CRCs begin as preexisting adenomas,[2] among which advanced adenomas (AAs) have been demonstrated to be a more intense risk factor.[3] Exploring the underlying mechanism of AA-CRC transformation is helpful in providing a basis for the precise treatment of CRC. [Extracted from the article]