Mpox and Sexually Transmitted Infection Testing in the Outpatient Primary Care Setting - Why LGBTQ Health Is Global Health Primary care clinicians play a vital role in screening, early diagnosis, and management to mitigate STIs and mpox outbreaks, particularly in LGBTQ and young adults who are often the most vulnerable patient populations at highest risk. In a large epidemiologic investigation in the current outbreak, viral prodromes varied and the majority of patients presented with anogenital skin lesions.[3]-[5] Most concerning, some patients reported only a solitary anogenital lesion as is common in many sexually transmitted infections (STI),[3],[4] with many cases involving men who have sex with men (MSM). Mpox, an orthopoxvirus first diagnosed in humans in 1970 in the Democratic Republic of the Congo, is the cause of an ongoing outbreak in the USA that risks becoming endemic.[1],[2] Rapid mpox recognition in the outpatient setting is essential to appropriately triage care and contain exposure risk. [Extracted from the article]