Multicomponent Synthesis of 5‐Cyano‐pyrazolo[1,5‐a]pyrimidines Enabled by Aerobic Manganese Catalysis.
- Resource Type
- Article
- Authors
- Qu, Heng‐Tong; Wu, Zeng‐Hui; Zhong, Guo‐Chen; Zhang, Yan‐Chun; Feng, Cheng‐Tao; Xu, Kun
- Source
- Advanced Synthesis & Catalysis. 3/21/2023, Vol. 365 Issue 6, p871-876. 6p.
- Subject
- *MANGANESE
*CATALYSIS
*PYRIMIDINES
*MACROCYCLIC compounds
*PROPYLENE carbonate
*NORMAL-phase chromatography
- Language
- ISSN
- 1615-4150
Multicomponent Synthesis of 5-Cyano-pyrazolo[1,5-a]pyrimidines Enabled by Aerobic Manganese Catalysis Keywords: Manganese catalysis; Strecker reaction; Multicomponent reaction; Cyanation EN Manganese catalysis Strecker reaction Multicomponent reaction Cyanation 871 876 6 03/27/23 20230321 NES 230321 An aerobic Mn(III)-catalyzed one-pot three-component synthesis of 5-cyano-pyrazolo[1,5- I a i ]pyrimidines has been described. These results revealed that the tandem reaction starts with the Strecker reaction and Mn(OAc) SB 3 sb - 2H SB 2 sb O is essential in the following oxidative cyclization process. All of these control experiments strongly support that this tandem reaction involves the Strecker reaction and the sequential Mn-catalyzed cyclization to afford the desired product B 4 aa b . [Extracted from the article]