Sepsis is the leading cause of death in childhood. The pediatric population has its own characteristics in relation to the adult population. Only a small number of clinical studies have been conducted and therefore the treatment of septic shock in children is one of the greatest therapeutic challenges in intensive care units. It is estimated that over 7 million children die each year from sepsis. Septic shock in children is defined as severe infection accompanied by cardiovascular dysfunction (including hypotension, perfusion disorder, and use of vasoactive drugs), while organ dysfunction associated with sepsis in children is defined as severe infection leading to cardiovascular and/or non-cardiovascular organ dysfunction. Timely recognition, rapid diagnosis, blood culture, rapid application and appropriate choice of antimicrobial drug, fluid therapy, use of vasoactive drugs, mechanical ventilation, enteral nutrition, increase the possibility of a positive treatment outcome. In order to respond to this challenge, it is necessary to continuously monitor the news from this field and apply them in practice by each individual, along with the multidisciplinary engagement of experts from different fields - pediatricians, microbiologists, infectious disease specialists, clinical pharmacologists. [ABSTRACT FROM AUTHOR]