To examine the relationship between knowing that a friend or family member became ill with, or died from, COVID-19 and receiving a vaccine dose within four months of the FDA's Emergency Use Authorization. A national sample of 1,517 respondents were surveyed from April 7 to April 12, 2021, 1,193 of whom were eligible for the vaccine when the data were collected. Respondents who knew someone who became ill with COVID-19 (AOR = 2.32, 95 % CI 1.74–3.09) or knew someone who died (AOR = 2.29, 95 % CI 1.32–3.99) from COVID-19 were more likely to receive at least a single COVID-19 vaccine dose. Encouraging people to share their COVID-19 illness and bereavement experiences with their local network such as friends, families, social-networks and via social media might help increase vaccine uptake. [ABSTRACT FROM AUTHOR]