We demonstrate numerically and experimentally the generation of the supercontinuum (SC) in water-filled-cladding photonic crystal fiber (PCF). The fiber-based on fused silica glass with regular hexagonal lattice consists of seven rings of air holes in the cladding region, which are all infiltrated with water. As result, the flat spectrum with bandwidths of 102.5 nm around the central pumping wavelength was achieved with input energy of 9.0 nJ and pulse duration of 400 fs at 1030 nm central wavelength, where the SC is mainly generated from the self-phase modulation (SPM). In addition, the chromatic dispersion of the investigated fiber was measured over a wide wavelength range from 0.6 to 1.75 μm using the Mach–Zehnder interferometer configuration and then verified against simulated results. [ABSTRACT FROM AUTHOR]