The TI group showed a lower titre of NA ( I p i < 0.005) and spike-specific T-cell immunity, both in the proportion of responders ( I p i < 0.001) and in the magnitude of the response ( I p i < 0.001). Dear Editor, Vaccines against SARS-CoV-2 have been an invaluable weapon to help combat the pandemic, and their use has been recommended by dermatologic societies even in patients under treatment with targeted immunosuppressors (TI)[1]; however, data regarding the effect of TI on the long-term immune response to the vaccines are still lacking. [Extracted from the article]