Photoinduced α‐Alkylation of Tetrahydroisoquinolines with Organoboron Reagent Enabled by Organic Photocatalyst.
- Resource Type
- Article
- Authors
- Wang, Pu; Meng, Ke; Guo, Shi‐Huan; Wang, Meng‐Yue; Gao, Ya‐Ru; Wang, Yong‐Qiang
- Source
- European Journal of Organic Chemistry. 2/6/2023, Vol. 26 Issue 6, p1-5. 5p.
- Subject
- *TETRAHYDROISOQUINOLINES
*POISONS
*ALLYLATION
*OXIDIZING agents
*ALKYLATION
*PHOTOCATALYSIS
- Language
- ISSN
- 1434-193X
We describe an efficient method for α‐functionalization of N‐aryl‐tetrahydroisoquinolines under visible‐light‐irradiation catalyzed by organic photocatalyst. This protocol provides a concise and environmental approach for the rapid allylation and benzylation of N‐aryl‐tetrahydroisoquinolines, and shows broad substrate scope. Stable organoboron reagents have shown their ability in the construction of challenging Csp3−Csp3 bond. The load of the photocatalyst is low and the oxidant is inexpensive and less toxic. [ABSTRACT FROM AUTHOR]