α-SnWO4 nanoparticles were synthesized on SiO2 grafted with amino functional groups (NH2-SiO2) using a one-step solvothermal method to achieve the purpose of deep desulfurization (< 10 ppm). The characterization results indicated that well-dispersed 3% α-SW/NS was successfully synthesized. The catalysts displayed excellent dibenzothiophene (DBT) removal performance at 30 °C for 1.5 h, and the regeneration ability was improved compared with 3% α-SnWO4/SiO2 (α-SW/S). Catalyst deactivation was investigated, and the results show that loss of W element with oxidation of Sn2+ result in the low stability of 3% α-SW/S, whereas only W leaching occurs in 3% α-SW/NS. Reaction mechanism prove that main reactive species are ·OH and electron transport in the reaction. Highly dispersed SnWO4/NH2-SiO2 with acid potential and electronic transmission performance was prepared by in-situ synthesis method for oxidative desulfurization reaction. Meanwhile, NH2- was beneficial to improve the catalyst stability, electronic transmission performance and the valence stability of Sn2+ under mild reaction conditions (temperature = 30 °C). [ABSTRACT FROM AUTHOR]