Design and Synthesis of Novel Helix Mimetics Based on the Covalent H-Bond Replacement and Amide Surrogate.
- Resource Type
- Article
- Authors
- Liu, Junyang; Tang, Shoubin; Yan, Jia-Lei; Ye, Tao
- Source
- Molecules. Jan2023, Vol. 28 Issue 2, p780. 14p.
- Subject
- *AMINO acid sequence
*PEPTIDES
*HYDROGEN bonding
*HIGH temperatures
*PROTEIN-protein interactions
*AMIDES
- Language
- ISSN
- 1420-3049
A novel hydrogen bond surrogate-based (HBS) α-helix mimetic was designed by the combination of covalent H-bond replacement and the use of an ether linkage to substitute an amide bond within a short peptide sequence. The new helix template could be placed in position other than the N-terminus of a short peptide, and the CD studies demonstrate that the template adopts stable conformations in aqueous buffer at exceptionally high temperatures. [ABSTRACT FROM AUTHOR]