Production of medical isotope 68Ge based on a novel chromatography separation technique and assembling of 68Ge/68Ga generator.
- Resource Type
- Article
- Authors
- Wang, Jieru; Gao, Ruiqin; Cao, Shiwei; Qin, Zhi; Lin, Mu; Huang, Qinggang; Yao, Zeen
- Source
- Applied Radiation & Isotopes. Feb2023, Vol. 192, pN.PAG-N.PAG. 1p.
- Subject
- *CHROMATOGRAPHIC analysis
*RADIOCHEMICAL purification
*COLUMN chromatography
*ISOTOPES
*NUCLEAR medicine
- Language
- ISSN
- 0969-8043
A double-column chromatography separation technique was involved for isolation of 68Ge from a bombarded Ga–Ni alloy target. About 185 MBq 68Ge obtained was used for assembling SnO 2 -based 68Ge/68Ga generator. Approximately 70% of 68Ga in high radioactivity concentration was eluted from generator with excellent radionuclidic, radiochemical and chemical purity. 68Ga was quite adequate for radiolabeling with DOTATATE or PSMA-617 with a high labelling efficiency of >92%. The double-column chromatography technique possessed a potential application prospect of 68Ge/68Ga production, aiding the development of 68Ga in nuclear medicine. • A double-column chromatography separation technique was adopted to isolate 68Ge from an irradiated Ga–Ni alloy target. • A SnO 2 -based 68Ge/68Ga generator has been assembled successfully. • Th e 68Ga eluates with excellent purity was labelled with DOTATATE and PSMA-617 with a high efficiency of >92%. [ABSTRACT FROM AUTHOR]