Chaperone-mediated autophagy regulates adipocyte differentiation.
- Resource Type
- Article
- Authors
- Kaushik, Susmita; Juste, Yves R.; Lindenau, Kristen; Shuxian Dong; Macho-González, Adrián; Santiago-Fernández, Olaya; McCabe, Mericka; Singh, Rajat; Gavathiotis, Evripidis; Cuervo, Ana Maria
- Source
- Science Advances. 11/18/2022, Vol. 8 Issue 46, p1-15. 15p.
- Subject
- *ADIPOGENESIS
*FAT cells
*PROTEASOMES
*LIPOLYSIS
*MOLECULAR biology
*TRANSFORMING growth factors-beta
- Language
- ISSN
- 2375-2548
The article presents a study which reported the activation of chaperone-mediate autophagy (CMA) during adipocyte differentiation and showed that CMA regulates adipogenesis through timely degradation of key regulatory signaling proteins and transcription factors that dictate proliferation, energetic adaptation and signaling changes needed for adipogenesis. Topics include effect of blocking CMA on adipocyte differentiation and importance of CMA for preadipocyte commitment to differentiation.