Lymphocyte subpopulations in the blood of sheep persistently infected with Border disease virus.
- Resource Type
- Article
- Authors
- Burrells, C.; Nettleton, P. F.; Reid, H. W.; Miller, H. R. P.; Hopkins, J.; McConnell, I.; Gorrell, M. D.; Brandon, M. R.
- Source
- Clinical & Experimental Immunology. Jun1989, Vol. 76 Issue 3, p446-451. 6p.
- Subject
- *LYMPHOCYTES
*LEUCOCYTES
*T cells
*VIRUSES
*IMMUNOGLOBULINS
*INFECTION
*SHEEP
- Language
- ISSN
- 0009-9104
The surface phenotypes of peripheral blood lymphocytes in groups of lambs and adult sheep persistently infected with Border disease virus (P-I BD) were compared with those of healthy controls. The proportion and number of lymphocytes bearing surface immunoglobulin (sIg+) and expressing class II MHC antigen (B cells) were significantly increased. A significant increase in CD1 + lymphocytes was also evident. Conversely, the proportion of T lymphocytes in P-I BD lambs was reduced. A marked reduction in the proportion of circulating lymphocytes expressing class I MHC antigen was also observed. These findings were not affected by differences in the strain of the virus responsible for the persistent infection. [ABSTRACT FROM AUTHOR]