AlCoCrFeNiTi high-entropy alloy (HEA) coatings were prepared on the surface of AISI 1045 steel by synchronous powder-feeding laser cladding. The empirical relationship among laser power, scanning speeds, powder feeding voltages, microhardness, and wear volumes was established by applying the response surface methodology (RSM). Results showed that the coating consisted of BCC and TiC phases, and there was good metallurgical bonding between the substrate and coating. The RSM showed that microhardness increased with increased laser power and feeding voltages and decreased with increased scanning speeds. The wear volume increased with increased scanning speeds and decreased with increased laser power and feeding voltages. Maximum microhardness and minimum wear volume were obtained using the optimized processing parameters. Errors between the predicted and actual values of coating microhardness and wear volume were 0.43 and 2.48%, respectively, which verified the accuracy of the established model. Research results provide a theoretical basis for the control and prediction of the properties of HEA coatings and the optimization of process parameters. [ABSTRACT FROM AUTHOR]