Pulmonary delivery of liposomes co-loaded with SN38 prodrug and curcumin for the treatment of lung cancer.
- Resource Type
- Article
- Authors
- Gao, Chengzhi; Zhang, Lanfang; Xu, Minhao; Luo, Yi; Wang, Ben; Kuang, Meiyan; Liu, Xingyou; Sun, Meng; Guo, Yue; Teng, Lesheng; Wang, Chenhui; Zhang, Yan; Xie, Jing
- Source
- European Journal of Pharmaceutics & Biopharmaceutics. Oct2022, Vol. 179, p156-165. 10p.
- Subject
- *LUNG cancer
*CURCUMIN
*LIPOSOMES
*CANCER treatment
*LUNG diseases
- Language
- ISSN
- 0939-6411
[Display omitted] • SN38 prodrug and curcumin co-loaded liposome (Lip-TAT-PEG-SN38/CUR) is prepared by a microfluidic method. • Drug concentration of lung cancer lesions can be increased by pulmonary delivery. • Cell-penetrating peptide TAT can contribute to the uptake of Lip-TAT-PEG-SN38/CUR. • Lip-TAT-PEG-SN38/CUR has strong effect against lung cancer in a B16F10 model under pulmonary delivery. A co-delivery system of SN38 (7-ethyl-10-hydroxyl camptothecin) prodrug and CUR (curcumin) was designed for the treatment of lung cancer by pulmonary delivery. SN38 was linked to cell-penetrating peptide (CPP) TAT via a polyethylene glycol (PEG) linker to form the SN38 prodrug (TAT-PEG-SN38). Liposomes co-loaded with amphiphilic TAT-PEG-SN38 and curcumin (Lip-TAT-PEG-SN38/CUR) were successfully prepared by a microfluidic method for the treatment of lung cancer via pulmonary delivery. Lip-TAT-PEG-SN38/CUR showed nanometer-sized sphericity and a particle size of 171.21 nm. Besides, Lip-TAT-PEG-SN38/CUR exhibited enhanced antiproliferative effect, increased cell apoptosis induction and improved cell cycle arrest compared to the single agents in vitro. The combination induced significant tumor inhibition in a BALB/c mouse lung cancer model. These results indicated that our SN38 prodrug and curcumin co-delivery system was a promising candidate for lung cancer treatment. [ABSTRACT FROM AUTHOR]