Melon (Cucumis melo) is an important vegetable crop grown in different parts of India. Hitherto in India melons were reported to be attacked by RNA containing viruses only. During the present study a whitefly transmitted ssDNA containing begomovirus tomato leaf curl Palampur virus (ToLCPalV) was observed to infect muskmelon crop in Punjab. Infection of this virus leads to the production of yellows and leaf curl type symptoms in the infected plants. Exploitation of host plant resistance is an effective, economical, ecologically safe and durable approach of disease management. Along with these considerations 75 genotypes of muskmelon, snap melon and wild melon were screened against prevalent begomovirus at Vegetable Research Farm, Department of Vegetable Science, Punjab Agricultural University, Ludhiana during 2017 and 2018. Among 75 accessions screened under field conditions, 45 accessions were highly susceptible with disease incidence >60%, whereas, 10 entries showed resistance response with per cent disease incidence ranging between 20 to 40%, six accessions categorized under highly resistance response with 0.1–20% disease incidence and four accessions were found to be immune with no apparent symptoms. The 20 accessions showing resistance, highly resistance and immune response under field condition were further screened under artificial condition using mass inoculation technique against ToLCPalV along with four susceptible checks. Under artificial screening two accessions (SM/IC 267375 and WM-11) were highly resistant, seven accessions were resistant whereas, two accessions were moderately resistant. Based on screening of F2 population of crosses between MS-1(susceptible parent) x MM-Selection-103 (resistant parent) revealed monogenic dominant resistance in MM-Selection-103. This is the first record of a monogenic dominant resistant source in melon against a begomovirus. [ABSTRACT FROM AUTHOR]