Objectives: To report on the overall survival outcomes and subgroup analysis of the LACC trial after all patients have completed surveillance at 4.5 years. Methods: Prospective non-inferiority randomized trial of patients with FIGO 2009 stage IA1 (LVSI)-IB1 cervical cancer with histologic subtype of squamous-cell carcinoma, adenocarcinoma, or adenosquamous carcinoma who underwent open or minimally invasive surgery. The aim of this analysis is to report on final overall survival outcomes at 4.5 years with all patients completing follow-up. Subgroup analysis will be performed to determine outcomes based on factors that might impact rates of recurrence and disease-specific survival. Results: A total of 631 patients (319 MIS and 312 open surgery) were evaluated. The rate of disease-free survival at 4.5 years will be reported for both surgical approaches. Rates of overall survival will also be reported. Sub-group analysis evaluating recurrence rates and disease-free survival for minimally invasive surgery vs open surgery will be performed stratifying by rates of tumor size (<2 cms), prior conization, and residual disease in the hysterectomy specimen. Site of recurrences for both groups will be evaluated as well as percentage of recurrences manifesting as carcinomatosis. Conclusions: Outcomes and subgroup analysis for complete follow-up of patients undergoing open vs minimally invasive radical hysterectomy will be provided. [ABSTRACT FROM AUTHOR]