A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury.
- Resource Type
- Article
- Authors
- Liu, Chuanhao; Zhou, Lin; Zheng, Ying; Man, Huizi; Ye, Zhiwei; Zhang, Xinfu; Xie, Lijuan; Xiao, Yi
- Source
- Chemical Communications. 9/16/2022, Vol. 58 Issue 72, p10052-10055. 4p.
- Subject
- *LIVER injuries
*VISCOSITY
*LIVER cells
*CELL imaging
*ROTORS
- Language
- ISSN
- 1359-7345
We proposed to monitor the early stage of alcohol-induced liver injury through quantitatively detecting Golgi viscosity. Therefore, the first Golgi-targeted fluorescent rotor (GA-Vis) was developed. With the aid of GA-Vis, the changes in Golgi viscosity during alcohol-induced liver injury were quantitatively evaluated by fluorescence lifetime imaging in live cells and zebrafish. GA-Vis was qualified as a practical tool for future diagnoses of alcohol-induced liver injury. [ABSTRACT FROM AUTHOR]