Cycling and activated CD8+ T lymphocytes and their association with disease severity in influenza patients.
- Resource Type
- Article
- Authors
- Liu, Shuai; Huang, Zhisheng; Fan, Ruyue; Jia, Ju; Deng, Xiaoyan; Zou, Xiaohui; Li, Hui; Cao, Bin
- Source
- BMC Immunology. 9/5/2022, Vol. 23 Issue 1, p1-9. 9p.
- Subject
- *INFLUENZA
*T cells
*BIOMARKERS
*FLOW cytometry
*HOSPITAL patients
- Language
- ISSN
- 1471-2172
Background: T cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T cells. It is necessary to clarify the T cells characteristics of kinetic changes and their correlation with disease severity. Methods: In a cohort of hospitalized influenza patients with varying degrees of severity, we characterized lymphocyte populations using flow cytometry. Results: The numbers of cycling (Ki67+) T cells at the acute phase of severe influenza were higher, especially in the memory (CD45RO+) T cell subsets. T cells from hospitalized influenza patients also had significantly higher levels of the exhausted marker PD-1. Cycling status of T cells was associated with T cell activation during the acute phase of influenza infection. The recruitment of cycling and activated (CD38+HLA-DR+) CD8+ T cells subset is delayed in severe influenza patients. Conclusions: The increased numbers of cycling memory (Ki67+CD45RO+) T cells subsets and delayed kinetics of activated (CD38+HLA-DR+) CD8+ T cells, could serve as possible biological markers for disease severity. [ABSTRACT FROM AUTHOR]