Current understanding of autoantibody against angiotensin II type 1 receptor in preeclampsia.
- Resource Type
- Article
- Authors
- Wang, Zheng; Feng, Weiyi; Liu, Jinjun
- Source
- Journal of Maternal-Fetal & Neonatal Medicine. Nov2022, Vol. 35 Issue 21, p4089-4094. 6p.
- Subject
- Language
- ISSN
- 1476-7058
Preeclampsia (PE) remains a leading cause of fetal and maternal mortality. Angiotensin II type 1 receptor autoantibody (AT1-AA) is implicated in the dysregulation of the renin-angiotensin-aldosterone system. A strong relationship between AT1-AA and the occurrence and severity of PE has been confirmed in previous literature. Recent evidences suggested that AT1-AA was responsible for blood pressure elevation, reactive oxygen species synthesis, and inflammatory factors release and engaged in multiple signaling cascades. The inhibition of AT1-AA might be a potential therapeutic target in future days. Here we reviewed the current understanding of AT1-AA, aiming to provide clarity surrounding the role of AT1-AA in PE. [ABSTRACT FROM AUTHOR]