Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma.
- Resource Type
- Case Study
- Authors
- Ishii, Hiroki; Tsujikawa, Takahiro; Oishi, Naoki; Kinouchi, Arisa; Sakamoto, Kaname; Mitsuda, Junichi; Ogi, Hiroshi; Itoh, Kyoko; Kondo, Tetsuo; Hirano, Shigeru; Sakurai, Daiju
- Source
- Clinical Case Reports. Jul2022, Vol. 10 Issue 7, p1-5. 5p.
- Subject
- *IMMUNE checkpoint proteins
*THYMUS tumors
*PROGRAMMED cell death 1 receptors
*CARCINOMA
*METASTASIS
*PROGRAMMED death-ligand 1
- Language
- ISSN
- 2050-0904
Metastatic intrathyroid thymic carcinoma (ITTC) is a rare cancer with no effective drugs for controlling. This case report has shown genomic and immune microenvironment profiles in metastatic ITTC and emphasized an immunosuppression via a PD‐1/PD‐L1 pathway, possibly strengthening the rationale for immune checkpoint blockade as a novel treatment. [ABSTRACT FROM AUTHOR]