A new base editor CGBE with a uracil DNA N-glycosylase (UNG) has recently been reported that enables efficient C-to-G editing in mammalian cells (Kurt I et al i ., 2021). Keywords: Cas9; base editing; rice; CGBE; UNG EN Cas9 base editing rice CGBE UNG 1238 1240 3 07/01/22 20220701 NES 220701 Cytosine and adenosine base editors (CBE and ABE) have been vigorously developed in plants, but the base conversion types are limited (Ren I et al i ., 2018, 2021; Xu I et al i ., 2021). Efficient C-to-G editing in rice using an optimized base editor Protoplasts-based assays revealed a substantial increase in the C-to-G/A editing efficiency compared with CBE (0.49% vs 0.12%), indicating C-to-G/A editing feasibility (Figure 1c). [Extracted from the article]