A receptor-targeting AIE photosensitizer for selective bacterial killing and real-time monitoring of photodynamic therapy outcome.
- Resource Type
- Article
- Authors
- Wang, Cheng; Wang, Jiaxin; Xue, Ke; Xiao, Minghui; Sun, Zhencheng; Zhu, Chunlei
- Source
- Chemical Communications. 6/25/2022, Vol. 58 Issue 50, p7058-7061. 4p.
- Subject
- *PHOTODYNAMIC therapy
*PHOTOSENSITIZERS
*METHICILLIN-resistant staphylococcus aureus
*GRAM-negative bacteria
*PHOTOSENSITIZATION
- Language
- ISSN
- 1359-7345
A receptor-targeting AIE photosensitizer (CE-TPA) is synthesized by conjugating cephalothin with a cationic D–A type AIE photosensitizer for selective killing of Gram-positive bacteria over Gram-negative bacteria and normal mammalian cells. By virtue of the strong photosensitization capability, CE-TPA exhibits efficient killing against Gram-positive methicillin-resistant Staphylococcus aureus. More importantly, the photodynamic bactericidal outcome can be conveniently reflected in a real-time fashion by the polarity-sensitive property of CE-TPA. [ABSTRACT FROM AUTHOR]