E-site drug specificity of the human pathogen Candida albicans ribosome.
- Resource Type
- Article
- Authors
- Zgadzay, Yury; Kolosova, Olga; Stetsenko, Artem; Cheng Wu; Bruchlen, David; Usachev, Konstantin; Validov, Shamil; Jenner, Lasse; Rogachev, Andrey; Yusupova, Gulnara; Sachs, Matthew S.; Guskov, Albert; Yusupov, Marat
- Source
- Science Advances. 5/27/2022, Vol. 8 Issue 21, p1-7. 7p.
- Subject
- *RIBOSOMES
*CANDIDA albicans
*RENILLA luciferase
*RIBOSOMAL proteins
*NUCLEIC acids
*MOLECULAR biology
- Language
- ISSN
- 2375-2548
The article discusses that Candida albicans is a widespread commensal fungus with substantial pathogenic potential and steadily increasing resistance to current antifungal drugs. The fungus is known to be resistant to cycloheximide (CHX) that holds on to the E–transfer RNA binding site of the ribosome.