α‐Asaronol [or (E)‐3′‐hydroxyasarone; systematic name: (E)‐3‐(2,4,5‐trimethoxyphenyl)prop‐2‐en‐1‐ol; C12H16O4] was synthesized towards the development of a potential antiepileptic drug. Following purification by recrystallization, single crystals of α‐asaronol were obtained by a liquid interface diffusion method at room temperature. The product was characterized by 1H and 13C NMR, and FT–IR spectroscopic analysis. X‐ray crystallography revealed the title crystal to belong to the orthorhombic space group P212121. Preliminary bioassays with mouse neuroblastoma N2a cells demonstrated the neuroprotective activities of the synthesized α‐asaronol. [ABSTRACT FROM AUTHOR]