Palladium‐Catalyzed Monofluoroalkylation of Aryl Iodides and Aryl Bromides with Nucleophilic Ethyl 2‐Fluoro‐2‐(trimethylsilyl)acetate.
- Resource Type
- Article
- Authors
- Zheng, Kaiting; Liu, Yaomei; Zheng, Chenggong; Yan, Fangpei; Xiao, Hua; Feng, Yi‐Si; Fan, Shilu
- Source
- Advanced Synthesis & Catalysis. Mar2022, Vol. 364 Issue 6, p1069-1073. 5p.
- Subject
- *ARYL bromides
*BIOACTIVE compounds
*ARYL iodides
*ACETATES
*NUCLEOPHILES
- Language
- ISSN
- 1615-4150
A palladium‐catalyzed monofluoroalkylation of aryl iodides and aryl bromides was developed using nucleophilic ethyl 2‐fluoro‐2‐(trimethylsilyl)acetate as a monofluoroalkyl source. The transformation proceeded with excellent substrate scope to afford a range of monofluoroalkylated products in good yields under mild conditions, and it proved feasible in a gram‐scale reaction. This protocol was successfully used in late‐stage modification of an estrone derivative, providing a facile route for research on the discovery of biologically active compounds and high‐performance materials. [ABSTRACT FROM AUTHOR]