Introduction. To our knowledge, currently no consensus or guidelines exist regarding perioperative and post-operative analgesia management in renal transplant recipients. Methods. We conducted an observational prospective clinical study to evaluate the analgesia management practice in kidney transplant recipients. All consecutive patients who underwent kidney transplant surgery were enrolled in this observational clinical study. According to current analgesia management practice in our institution, patients were divided in two groups: patients who received general anesthesia and epidural analgesia were group E, and patients who received general anesthesia and i.v. analgesia were group G. The primary outcome measure in this study was VAS score and 24 h analgesia requirements. The second outcome measures were com-plications and/or side effects related to analgesia treatment. Results. Group E had lower VAS pain score both at rest and on movement but only in the first 2 h, (VAS at rest E. 3.1±0.3 vs. G. 4.0±0.3, VAS on movement E. 4.2±0.6 vs. G. 4.5±0.3, p<0.05). The pain score by VAS scale did not differ between the groups at 6 h, 12 h and 24 h postoperatively, p=NS. Additionally, a small differrence was noticed in side effects. Patients in group E had reported more side effects than patients in group G. Conclusion. The study highlighted the variety in clinical practice regarding anesthesiologist preferences for pain management in kidney transplant recipients. This evaluation did not show any difference between anesthetic techniques and clinical results. [ABSTRACT FROM AUTHOR]