Keywords: cardiomyocytes; heart failure; inhalation; microRNAs; nanoparticles; RNA; therapeutics EN cardiomyocytes heart failure inhalation microRNAs nanoparticles RNA therapeutics 1973 1976 4 01/19/22 20211214 NES 211214 National Research Council-Institute of Genetics and Biomedical Research, Milan Unit, Italy (J.M. V.D.M. M.B.-S. P.C. G.C. M.M. D.C.). Here, inhalable CaPs loaded with synthetic miR-133a mimic (CaP-miR) were tested as a replacement therapy approach for the specific restoration of miR-133a levels in cardiomyocytes just within the precise time frame when the miRNA is pathologically repressed. [Extracted from the article]