Stability and change in epigenetic regulation of immune cells.
- Resource Type
- Article
- Authors
- Scott‐Browne, James; Shih, Han‐Yu
- Source
- Immunological Reviews. Jan2022, Vol. 305 Issue 1, p5-8. 4p.
- Subject
- *CELLULAR control mechanisms
*EPIGENETICS
*DNA-binding proteins
*TRANSPOSONS
*T cell receptors
*B cell differentiation
*T helper cells
- Language
- ISSN
- 0105-2896
Vitamin C also promotes the induced differentiation of regulatory T cells in vitro via TET proteins, enabling demethylation of critical STAT dependent enhancers in the I Foxp3 i locus and genome wide. Chen et al9 highlight the function of TET enzymes on B cell differentiation and function, which enable plasma cell differentiation and class switch recombination, by promoting expression of activation-induced cytidine deaminase (AID). The differentiation of a naive T cell after response to antigen stimulation is accompanied by a dramatic chromatin reorganization that determines downstream function and survival. T cell maturation in the thymus is dependent on close interactions with specialized epithelial cell subsets that enable thymocyte differentiation. [Extracted from the article]