Serious consequences of Epstein‐Barr virus infection: Hemophagocytic lymphohistocytosis.
- Resource Type
- Article
- Authors
- Xu, Lingyue; Guo, Xiaofang; Guan, Hongzai
- Source
- International Journal of Laboratory Hematology. Feb2022, Vol. 44 Issue 1, p74-81. 8p.
- Subject
- *HIV infections
*CLINICAL pathology
*HEMOPHAGOCYTIC lymphohistiocytosis
*GRAFT versus host disease
*DIFFERENTIAL diagnosis
*GENETIC testing
*MOLECULAR biology
*CYTOGENETICS
*EPSTEIN-Barr virus diseases
*DISEASE complications
- Language
- ISSN
- 1751-5521
Human is the host of the Epstein‐Barr virus (EBV) especially in childhood and adolescence. Most of them are asymptomatic infection and self‐limiting. However, for those patients who suffer from immune dysfunction, EBV infection will be life‐threatening. Epstein‐Barr virus‐associated hemophagocytic lymphohistocytosis (EBV‐HLH) is one of the severe effects. The diagnosis and differential diagnosis of EBV‐HLH and other EBV infectious diseases are mentioned in this paper. The molecular biology mechanism and complications of EBV‐HLH are equally briefly presented. It also provides a practical method for the genetic diagnosis of such diseases and the differential diagnosis with other human immunodeficiency diseases for medical scientists in routine clinical practice. [ABSTRACT FROM AUTHOR]