Synthesis of benzimidazole by mortar–pestle grinding method.
- Resource Type
- Letter
- Authors
- Zhang, Peng; Liu, Caiqin; Yu, Ling; Hou, Huiqing; Sun, Weiming; Ke, Fang
- Source
- Green Chemistry Letters & Reviews. Dec 2021, Vol. 14 Issue 4, p612-619. 8p.
- Subject
- *BENZOXAZOLES
*ACID catalysts
*ACETIC acid
*BENZIMIDAZOLES
*ALDEHYDES
*SUSTAINABLE chemistry
- Language
- ISSN
- 1751-8253
An environmentally friendly and efficient protocol for the synthesis of benzimidazoles by mortar–pestle grinding technique in the presence of acetic acid as a catalyst is reported. This mechanochemical method proceeded with the condensation of aldehyde and o-phenylenediamine followed by cyclization reaction, leading to the formation of the corresponding benzimidazoles in yields up to 97%. This protocol could also be applied for the synthesis of benzothiazoles and benzoxazoles. [ABSTRACT FROM AUTHOR]