Alpha-Synuclein and Cognitive Decline in Parkinson Disease.
- Resource Type
- Article
- Authors
- Fan, Tian-Sin; Liu, Sam Chi-Hao; Wu, Ruey-Meei
- Source
- Life (2075-1729). Nov2021, Vol. 11 Issue 11, p1239-1239. 1p.
- Subject
- *COGNITION disorders
*PARKINSON'S disease
*ALPHA-synuclein
*OLDER people
*NERVOUS system
- Language
- ISSN
- 2075-1729
Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement. [ABSTRACT FROM AUTHOR]