Cu/base co-catalyzed [3+3] cycloaddition for the synthesis of highly functionalized 4-fluoropyridines.
- Resource Type
- Article
- Authors
- Dong, Jinhuan; Feng, Wanzhong; Wang, Lei; Li, Mei; Chen, Zhe; Xu, Xianxiu
- Source
- Chemical Communications. 12/7/2021, Vol. 57 Issue 94, p12635-12638. 4p.
- Subject
- *ISOCYANIDES
*NUCLEOPHILES
*RING formation (Chemistry)
- Language
- ISSN
- 1359-7345
An efficient, straightforward and general method for the de novo synthesis of highly functionalized 4-fluoropyridines was developed via a cooperative copper- and base-catalyzed [3+3] cycloaddition of active methylene isocyanides with difluorocyclopropenes. The resulting 4-fluoropyridines can be readily diversified by various nucleophiles. [ABSTRACT FROM AUTHOR]