A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice.
- Resource Type
- Article
- Authors
- Denny, Paul; Hopes, Elaine; Gingles, Neill; Broman, Karl W.; McPheat, William; Morten, John; Alexander, Janet; Andrew, Peter W.; Brown, Steve D. M.
- Source
- Mammalian Genome. Jul2003, Vol. 14 Issue 7, p448-453. 6p.
- Subject
- *STREPTOCOCCACEAE
*BACTERIAL diseases
*GRAM-positive bacteria
*ENTEROCOCCUS
*LACTOCOCCUS
*COMMUNICABLE diseases
- Language
- ISSN
- 0938-8990
We have studied the genetics of susceptibility to infection by Streptococcuspneumoniae in mice. Linkage analysis of the F2 generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection. [ABSTRACT FROM AUTHOR]