In the article "Kidney organoid systems for studies of immune-mediated kidney diseases: Challenges and opportunities" ([9] in this issue), Stein et al. focus on organoids, a three-dimensional, multicellular culture system, as a state-of-the-art technology for studying immune cell-epithelial cell interactions and for the discovery of pathogenic pathways of immune-mediated kidney diseases. Interaction of the immune system with renal tissue cells Immune cells actively contribute to tissue damage in immune-mediated GN. Immune-mediated glomerular diseases (Glomerulonephritides, GN) represent a heterogeneous group of disorders. [Extracted from the article]