Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male.
- Resource Type
- Article
- Authors
- Pham, Khanh; Gottesdiener, Lee; Simon, Matthew S; Trzebucki, Alex; Maldarelli, Grace A; Cisse, Babacar; Lieberman, Joshua; DeHaan, Elliot; Pisapia, David
- Source
- Open Forum Infectious Diseases. Sep2021, Vol. 8 Issue 9, p1-5. 5p.
- Subject
- *SYPHILIS
*TREPONEMA pallidum
*RIBOSOMAL RNA
*RNA sequencing
*SPIROCHETES
*DIAGNOSIS
- Language
- ISSN
- 2328-8957
We present a case of a human immunodeficiency virus–negative man with syphilitic meningovascular disease with subjacent involvement of brain parenchyma leading to a mass-forming inflammatory lesion that was pathologically distinct from a typical gumma. Syphilis was diagnosed after tissue obtained from a brain biopsy demonstrated spirochetes consistent with Treponema pallidum and confirmed by 16S ribosomal RNA sequencing. [ABSTRACT FROM AUTHOR]