-glutamyltransferase (B) and AA (C) levels were assessed by ELISA in pGCs which were transfected with pcdna3.1, pc-GGT1-01, pc-GGT1-02, pc-GGT1- 1, and pc-GGT1- 2, respectively. (D) The cumulative weight gain of Ggt1+/+, Ggt1-/-, Ggt1+/+ +NAC and Ggt1-/-+NAC mice. Polycystic ovary syndrome (PCOS) is an autoimmune disease that is characterized by follicular growth arrest and chronic anovulation and linked with female infertility in 5%-20% of reproductive-aged women.1 -Glutamyltranspeptidase (GGT1), which is one of the membrane-associated enzymes in mammalian cells, may lead to an altered glucose metabolism and abnormal lipid profile that are main clinical phenotypes of PCOS.2 Here, we discovered that I Ggt1- i deficient female mice had similar phenotypes to those of women with PCOS. (A) qRT-PCR was performed for analyzing GGT1 exon 11 inclusion/skipping levels (XS% % = = GGT1-02/GGT1-01+GGT1-02). [Extracted from the article]