High miR-3650 expression in nasopharyngeal carcinoma and its clinical prognostic values.
- Resource Type
- Article
- Authors
- Ruan, Qiang; Yang, Xian-Zi; Zhu, Lin; He, Qing-Jun; Zhu, Si-Yu; Wen, Yue-Feng; Ma, Lei
- Source
- Pathology - Research & Practice. Aug2021, Vol. 224, pN.PAG-N.PAG. 1p.
- Subject
- *PROGNOSIS
*PROGRESSION-free survival
*NASOPHARYNX cancer
*OVERALL survival
*SURVIVAL analysis (Biometry)
*REGRESSION analysis
- Language
- ISSN
- 0344-0338
A recent study has reported that miR-3650 expression was significant reduced in hepatocellular carcinoma and predicted poor prognosis. However, the role of miR-3650 in nasopharyngeal carcinoma (NPC) remains indefinite. Total 140 cases of NPCs were included in this study. The expression of miR-3650 was determined in NPC tissues and adjacent nontumor tissues using qRT-PCR. Then the relationship between miR-3650 expression and clinicopathological features as well as survival were analyzed. The expression of miR-3650 was significant higher in NPC tissues than that in adjacent nontumor tissues (P < 0.001). High expression of miR-3650 was significant correlated with tumor progression and distant metastasis of NPC patients. And patients with high miR-3650 expression have much worse 5-year overall survival (OS) and 5-year progression-free survival (PFS) than those with low expression (all P < 0.0001). Furthermore, Cox regression analysis showed that miR-3650 was an independent risk predictor for OS and PFS in NPC patients (all P = 0.000). Our results demonstrated for the first time that miR-3650 was markedly upregulated in NPC tissues and positively associated with tumor progression and poor survival, suggesting that miR-3650 may be a potential novel prognostic biomarker and therapeutic target for NPC patients. [ABSTRACT FROM AUTHOR]